Fig. 5 | Scientific Reports

Fig. 5

From: IgM+IgD− B cells in human gut-associated lymphoid tissue have memory features and give rise to IgM+ and IgA+ antibody-secreting cells

Fig. 5

Separate repertoire profiling of CD27- and CD27 + subsets. Donors and samples include individuals who have sorted subsets (see Supplementary Table 1) but exclude the 12-hr-old donor. (A) Mean level of somatic hypermutation (SHM) by clone within each sorted population; (B) Distribution of clonal SHM levels, by subset; (C) VH gene usage in tonsil; (D) VH gene usage in appendix. Data were filtered as described in the methods section. Gating strategy for cell sorting (Supplementary Fig. 5).

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