Fig. 3
From: A new class of human CpG Island promoters with primate-specific repeats
Reprogramming of TR-CGIs, non-TR CGIs and ICRs (A) Changes in methylation of TR-CGIs (blue), non-TR CGIs (red), and ICRs (green) during reprogramming of tissue to primed iPSCs. Dots are different tissues from which iPSCs were derived. (B–D) Principal Components Analysis (PCA) of ICRs, nonTR-CGIs and TR CGIs based on their methylation levels in the multiple tissues and their iPSCs. The dots represent different samples. (E) Percentages of the three sequence classes (TR-CGIs, non-TR CGIs and ICRs) undergoing methylation changes (≥20%) in transition from BJ fibroblasts to either naïve or primed iPSCs. The results were obtained after analysis of publicly available datasets: GSE200834, GSE76970, GSE110366, GSE76641.
