Fig. 2 | Scientific Reports

Fig. 2

From: Sodium formate-induced mitochondrial impairment and cytotoxicity in neuronal cells reveal crucial pathogenic mechanisms underlying diabetic neuropathy and retinopathy

Fig. 2

Copyright permission for the use of the KEGG database in this analysis has been obtained. (B) Effect of 12.5 and 25 mM SF (48-h treatment) on the expression of selected genes. Note that the RNA-seq and transcriptomic analysis were repeated twice, and one representative data set is shown here. Each quantitative value is the mean ± S.D (n = 3). Note that the mean intensity value for each control group is labeled in white numerical number in the black bar. * and ** denote for P < 0.05 and P < 0.01, respectively, compared to the respective control group.

Transcriptomic analysis of SF-treated HT22 cells. (A) The KEGG disease enrichment plot of genes 24,25,26 showing SF-induced significant changes. The cells were treated with SF at 12.5 and 25 mM for 48 h, and then harvested for RNA-seq and transcriptomic analysis.

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