Table 1 Baseline characteristics of the overall population, Decreasing, and stably high groups in eICU database. AST: aspartate aminotransferase; ALT: Alanine aminotransferase; WBC: white blood cell count; RBC: red blood cell count; BUN: blood Urea nitrogen; LDH: lactate dehydrogenase; MAP: mean atrial pressure; GCS: Glasgow coma scale; CKD: chronic kidney disease7.
Overall | Decreasing | Stably High | p | |||
|---|---|---|---|---|---|---|
N | 317 | 131 | 186 | |||
Age | 62.00 [48.00, 71.00] | 63.00 [49.50, 73.00] | 61.50 [48.00, 70.00] | 0.187 | ||
Sex (%) | 1 | |||||
Female | 135 (42.6) | 56 (42.7) | 79 (42.5) | |||
Male | 182 (57.4) | 75 (57.3) | 107 (57.5) | |||
Ethnicity (%) | 0.805 | |||||
White | 240 (75.7) | 99 (75.6) | 141 (75.8) | |||
Black | 49 (15.5) | 19 (14.5) | 30 (16.1) | |||
Other | 28 (8.8) | 13 (9.9) | 15 (8.1) | |||
Hemoglobin | 9.45 [8.24, 11.25] | 9.72 [8.43, 11.53] | 9.08 [8.15, 11.06] | 0.037 | ||
WBC | 11.95 [8.38, 17.70] | 13.25 [9.52, 17.68] | 11.24 [7.50, 17.70] | 0.016 | ||
RBC | 3.20 [2.78, 3.80] | 3.42 [2.90, 3.91] | 3.07 [2.72, 3.71] | 0.005 | ||
Platelets | 144.00 [81.00, 224.00] | 209.00 [149.00, 287.50] | 100.50 [61.25, 163.75] | < 0.001 | ||
AST | 53.75 [27.00, 115.00] | 36.00 [22.62, 68.00] | 66.50 [33.62, 174.38] | < 0.001 | ||
ALT | 34.12 [19.88, 73.62] | 27.25 [16.00, 53.25] | 42.00 [22.00, 90.00] | 0.001 | ||
Creatinine | 1.50 [0.90, 2.55] | 1.00 [0.68, 1.56] | 2.00 [1.29, 3.10] | < 0.001 | ||
BUN | 31.00 [19.04, 47.17] | 21.50 [15.40, 33.38] | 37.25 [24.12, 53.00] | < 0.001 | ||
LDH | 321.00 [235.00, 496.00] | 269.00 [198.00, 351.00] | 380.00 [270.00, 610.50] | < 0.001 | ||
Spo2 | 97.00 [95.00, 99.00] | 98.00 [96.00, 99.00] | 97.00 [95.00, 98.00] | 0.021 | ||
PH | 7.36 [7.32, 7.41] | 7.38 [7.33, 7.43] | 7.34 [7.31, 7.40] | < 0.001 | ||
Lactate | 1.86 [1.20, 2.88] | 1.61 [1.00, 2.19] | 2.20 [1.39, 3.63] | < 0.001 | ||
HCO3 | 21.10 [18.69, 24.40] | 21.85 [19.99, 26.04] | 20.14 [17.83, 23.44] | < 0.001 | ||
Sodium | 139.25 [135.50, 142.25] | 139.62 [136.92, 142.50] | 138.77 [135.02, 141.73] | 0.078 | ||
Potassium | 4.10 [3.77, 4.44] | 4.02 [3.72, 4.26] | 4.18 [3.80, 4.57] | 0.005 | ||
Heartrate | 94.00 [80.00, 107.00] | 91.00 [79.00, 104.50] | 97.00 [83.00, 109.00] | 0.062 | ||
Respiratory rate | 21.00 [17.00, 25.00] | 19.00 [16.00, 23.00] | 22.00 [18.00, 25.75] | < 0.001 | ||
Temperature | 37.00 [37.00, 37.00] | 37.00 [37.00, 37.00] | 37.00 [37.00, 37.00] | 0.103 | ||
MAP | 77.33 [71.67, 85.33] | 80.00 [73.17, 87.67] | 75.33 [71.00, 82.92] | < 0.001 | ||
ICU Stay | 11.08 [8.61, 16.10] | 10.92 [8.42, 16.23] | 11.22 [8.71, 16.04] | 0.567 | ||
Hospital Stay | 19.09 [13.21, 26.66] | 17.46 [12.30, 25.94] | 20.03 [13.78, 27.84] | 0.069 | ||
Clinical Score | ||||||
GCS | 8.00 [6.00, 12.00] | 7.00 [4.00, 11.00] | 8.00 [6.00, 12.00] | 0.086 | ||
APACHE | 81.00 [64.00, 102.00] | 77.00 [56.00, 96.50] | 83.50 [68.00, 104.75] | 0.010 | ||
Aki grade (%) | < 0.001 | |||||
1 | 91 (28.7) | 51 (38.9) | 40 (21.5) | |||
2 | 102 (32.2) | 50 (38.2) | 52 (28.0) | |||
3 | 124 (39.1) | 30 (22.9) | 94 (50.5) | |||
Comorbidity (%) | ||||||
Heart failure | 35 (11.0) | 13 (9.9) | 22 (11.8) | 0.726 | ||
Hypertension | 39 (12.3) | 15 (11.5) | 24 (12.9) | 0.83 | ||
Diabetes | 13 (4.1) | 6 (4.6) | 7 (3.8) | 0.941 | ||
CKD | 51 (16.1) | 13 (9.9) | 38 (20.4) | 0.019 | ||
Shock | 65 (20.5) | 14 (10.7) | 51 (27.4) | < 0.001 | ||
Sepsis | 109 (34.4) | 31 (23.7) | 78 (41.9) | 0.001 | ||
