Table 1 Comparison of Computational Approaches to Mitotic Checkpoint Modeling.
Aspect | Previous models | The integrated model |
|---|---|---|
Scope | Individual checkpoint pathways | Integrated SAC-SPOC crosstalk |
Modeling Approach | Complex, nonlinear mechanisms | Minimal, linear tension-dependent model |
Key Innovation | Pathway-specific dynamics | Unified checkpoint integration |
Tension Sensing | Complex sigmoid functions | Simple linear dependence |
Computational Complexity | High | Reduced, computationally tractable |
Operational Regimes | Limited | Four distinct checkpoint states |
Stochasticity Requirement | Essential for switch-like behavior | Deterministic ultrasensitivity |
