Fig. 1 | Scientific Reports

Fig. 1

From: Author Correction: Bmi-1 promotes the proliferation, migration and invasion, and inhibits cell apoptosis of human retinoblastoma cells via RKIP

Fig. 1

Knockdown of Bmi-1 inhibits cell proliferation, migration and invasion, and increases cell apoptosis. RT-qPCR (A) and Western blot (B) showed that the expression of Bmi-1 was higher in Y79, SO-RB50 and Weri-RB1 cells than that of normal retinal vascular endothelial cell line ACBRI-181. (C) MTT assay revealed that knockdown of Bmi-1 suppressed cell proliferation compared with control group at 24 h, 48 h and 72 h. (D) Wound healing displayed that Bmi-1 silencing reduced the migration of SO-RB50 cells (Scale bar: 500 μm) and Weri-RB1 cells (Scale bar: 500 μm). (E) Transwell assay displayed that Bmi-1 silencing reduced the invasion of SO-RB50 cells and Weri-RB1 cells (Scale bar: 200 μm). (F) FCM demonstrated that knockdown of Bmi-1 increased cell apoptosis. *P < 0.05, **P < 0.01, ***P < 0.001, compared to the ACBRI-181 cells or the Scramble group.

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