Fig. 5 | Scientific Reports

Fig. 5

From: Regulatory B cells drive immune evasion in the tumor microenvironment and are involved peritoneal metastasis in gastric cancer

Fig. 5

Analysis of regulatory B cells (Bregs) and immune cells in a B cell-specific Pten-deficient mouse model of peritoneal metastasis (PM). (A) Comparison of ascites volume and peritoneal tumor weight between Pten-deficient mice (n = 6) and control mice (n = 6) (**p < 0.01, ***p < 0.001). (B) Flow cytometry analysis of Breg frequency from the spleen, ascites, and peritoneal tumors in Pten-deficient mice and control mice (**p < 0.01, ***p < 0.001). Each group consisted of 6 mice. (C) Comparison of CD8+ T cells and M2 macrophages from the spleen, ascites, and peritoneal tumors between Pten-deficient mice and control mice (*p < 0.05, **p < 0.01). Each group consisted of 6 mice. The results are provided in terms of means ± standard deviation values.

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