Table 2 Univariate and multivariate analysis for prognostic factors in patients with peritoneal metastasis.

Variable		Number	Univariate analysis			Multivariate analysis
Variable		Number	HR	95% CI	p value	HR	95% CI	p value
Age, years	> 70/≦70	20/40	1.824	1.329–5.309	0.037	1.741	0.661–2.573	0.09
Sex	Male/female	26/34	1.204	0.712–2.037	0.4826
Performance status	0 /1, 2	50/10	2.471	0.945–6.457	0.0059	0.794	0.323–1.955	0.616
BMI	≦ 19.8/>19.8	30/30	0.949	0.561–1.604	0.8387
Histology (Nakamura’s classification)	Differentiated/undifferentiated	13/47	0.908	0.480–1.717	0.7509
Histology (Lauren’s classification)	Intestinal/diffuse and mixed	10/50	0.798	0.421–2.053	0.594
first-onset case/recurrent case	first-onset /recurrence case	53/7	0.961	0.440–2.097	0.9211
Size of PM	Bowel resection/biopsy or excision alone	17/43	1.067	0.608–1.873	0.8204
Location of resected PM	Visceral peritoneum/parietal peritoneum	47/13	1.150	0.603–2.191	0.6561
Chemotherapy	Yes/no	57/3	0.084	0.002–3.808	< 0.001	0.158	0.034–0.738	0.019
Intraperitoneal chemotherapy	Yes/no	32/28	0.809	0.473–1.382	0.4147
P stage	P1a/P1b, P1c	9/51	1.399	0.693–2.826	0.3972
CEA	>5/≦5	13/47	1.974	0.913–4.272	0.026	0.971	0.436–2.165	0.943
CA19-9	>37/≦37	14/46	1.509	0.729–3.123	0.1932
CA125	>35/≦35	20/40	1.480	0.822–2.665	0.1494
Platelet	≦ 223 × 10³/>223 × 10³	20/40	1.734	0.916–3.282	0.447
CRP	>1.0/≦1.0	9/51	1.505	0.658–3.444	0.250
PNI	≦ 40/>40	26/34	1.185	0.695–2.021	0.515
Breg frequency in primary lesion	>10.2/≦10.2	27/33	1.605	0.963–2.675	0.068
Breg frequency in PM	high/low	29/31	2.144	1.222–3.763	0.002	2.314	1.298–4.124	0.004

PM peritoneal metastasis, CRP C-reactive protein, PNI prognostic nutritional index, CEA carcinoembryonic, CA carbohydrate antigen, Breg regulatory B cel.

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