Table 1 Association between NMT1, TIMM17A, and the combination of the two on LUAD outcome data. Hazard ratios and confidence intervals for overall survival, disease specific survival, and disease-Free survival for the various categorical splits (rows). Whereas TIMM17A was independently associated with overall survival, disease specific survival, and disease-Free survival, NMT1 was only associated with overall survival. The presence of high NMT1 together with high TIMM17A expression significantly had a significant association with worse OS (P = 0.020 as compared to TIMM17A alone).
Overall survival n = 486, n-event 174 | Disease specific survival n = 446, n-event = 101 | Disease free survival n = 412, n-event = 175 | ||||
|---|---|---|---|---|---|---|
Hazard rate (95% CI) | P value | Hazard rate (95% CI) | P value | Hazard rate (95% CI) | P value | |
TIMM17A | ||||||
Low | Reference | 0.003 | Reference | 0.023 | Reference | 0.030 |
High | 1.59 (1.17, 2.17) | 1.60 (1.07, 2.40) | 1.40 (1.03, 1.91) | |||
NMT1 | ||||||
Low | Reference | 0.017 | Reference | 0.316 | Reference | 0.583 |
High | 1.52 ( 1.08, 2.14) | 1.27 (0.79, 2.07) | 1.12 (0.76, 1.64) | |||
Combined | ||||||
Low TIMM17A, Low NMT1 | Reference | < 0.001 | Reference | 0.023 | Reference | 0.049 |
High TIMM17A, High NMT1 | 2.43 (1.52, 3.89) | 2.10 (1.11, 3.99) | 1.71 (1.00, 2.91) | |||
Combined | ||||||
Others (Low–Low; Low–High; High–Low) | Reference | 0.001 | Reference | 0.040 | Reference | 0.135 |
High TIMM17A, High NMT1 | 1.99 (1.32, 2.99) | 1.82 (1.03, 3.22) | 1.45 (0.89, 2.35) | |||
P value - added NMT1 effect | 0.020 | 0.311 | 0.667 | |||
P value - NMT:TIMM17A interaction | 0.868 | 0.429 | 0.671 | |||
