Fig. 4

Effects of enhancing and inhibiting astrocytic activity in the dorsal striatum on LID severity in the 6-OHDA mouse model. (A) The total (ALO + LOC) AIM was scored every 20 min for 80 min on the tenth day of CNO and L-dopa administration. (B–F) The total LOC (B), ALO (C), axial (D), limb (E), and orofacial (F) AIM behaviors were scored every 20 min for 80 min on the tenth day of CNO and L-dopa administration. (G) The total (LOC + ALO) AIM scores. (H–J) The LOC (H), ALO (I), axial, limb, and orofacial (J) AIM scores. AAV8-GFAP-mCherry, n = 12; AAV8-hM4D(Gi)-mCherry, n = 11; AAV8-hM3D(Gq)-mCherry, n = 10. *p < 0.05, between the indicated groups (Kruskal–Wallis test, followed by Dunn’s multiple comparisons test). Box-and-whisker plots were presented with the median (horizontal bar) as the central measure, the box representing the interquartile range (25th to 75th percentiles), and the whiskers indicating the minimum and maximum values.