Fig. 7

PGRP-S enhances MAPK/ERK signaling via TTC1 in HCC cells. (A) Based on the TCGA-HCC dataset, functional enrichment analysis (GSEA) was applied to identify the biological pathways that may be affected by TTC1. The results were analyzed according to the enrichment and screening criteria of P < 0.05 and FDR q-values < 0.25. (B) GSEA analysis showed that Cell cycle was associated with high expression of TTC1. (C, D) Western blot analysis of p-RAF, RAF, p-MEK, MEK, p-ERK, ERK and cyclin D1 in indicated cells.