Fig. 4
From: Screening of the FDA-approved drug library identifies CCL17 inhibitors that block arthritic pain
Fluoxetine, ractopamine, ponesimod and terbutaline ameliorate arthritic pain-like behavior. C57BL/6 mice were intraarticularly injected with zymosan on day 0 and treated (intraperitoneal) with saline or fluoxetine, ractopamine, ponesimod, terbutaline and etravirine therapeutically on days 1 and 4. (A) Change in weight distribution (arthritic pain-like behavior) using incapacitance meter (n = 8/group), over time. (B) Disease (day 7, histologic score, n = 6–10 mice/group) and (C) joint Ccl17 and Ccl22 mRNA expression (day 7, qPCR; n = 5/group) were graphed as scatterplots with lines indicating mean ± SEM measured. P values were obtained using two-way ANOVA with Sidak post-test (A) or unpaired t test (B,C), where *p < 0.05, **< 0.01, *** <0.001. Histological images are presented in are presented in Supplementary Fig. 4.
