Fig. 1
From: An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction
Effects of different concentrations of sevoflurane on MEP and SSEP in rats. (a,b) Schematic diagrams illustrating the setup for MEP (a) and SSEP (b) recordings in rats. (c,d) Representative MEP and SSEP waveforms at baseline and after increasing concentrations of sevoflurane. (e) MEP amplitude significantly decreased in a dose-dependent manner starting at 0.6% sevoflurane, while latency remained unchanged (n = 6). (f) SSEP amplitude also decreased with increasing sevoflurane concentration, though less pronounced than MEP; latency gradually increased at higher doses (n = 6). (g) Dose-response curve of sevoflurane on MEP amplitude, showing IC50 = 0.52% and IC95 = 0.96%, both below the MAC for LORR ≈ 1.8%. (g) Representative MEP waveforms under different doses of propofol. Data are shown as mean ± SD. Statistical analysis: two-way ANOVA (e,f) and nonlinear regression (g); statistical significance: **P < 0.01, ****P < 0.0001 vs. baseline. IC50, 50% inhibitory concentration; IC95, 95% inhibitory concentration; MAC, Minimum alveolar concentration; LORR, loss of righting reflex; ED50, median effective dose.
