Fig. 6
From: An in vivo rat model for comparing selective blockade between sensory and motor nerve conduction
Evaluation of selective nerve blockade by QX-314/capsaicin. (a) Saline treatment showed no change in MEP or SSEP amplitude and latency over 30 min (n = 6). (b) Application of 10 mM QX-314 with 0.05% capsaicin suppressed SSEP amplitude progressively over time, with no significant changes in MEP (n = 6). (c) Increasing the QX-314 concentration to 20 mM further reduced SSEP amplitude, still without affecting MEP (n = 6). (d) Summary of 30 min time point showing no difference in MEP amplitude or latency across groups. (e) At 30 min, both 10 mM and 20 mM QX-314/capsaicin significantly reduced SSEP amplitude, while latency was mildly prolonged. (f,g) Comparative plots show the selective suppression of SSEP by QX-314/ capsaicin, confirming its sensory-selective nerve blockade effect. (h) Recovery time course following perineural injection of 20 mM QX-314/0.05% capsaicin, showing SSEP amplitude returning to baseline within 50 min while MEP amplitude remained stable throughout (n = 6). Data are shown as mean ± SD. Statistical analysis: two-way ANOVA (a,b,c,f,g) and one-way ANOVA (d,e); statistical significance: ns = not significant, **P < 0.01, ***P < 0.001, ****P < 0.0001.
