Table 4 Cytotoxic activity of Chelate 1 and Chelate 2 against folate receptor-positive and negative cell lines. The data were expressed as the mean ± SD of three independent experiments.

From: Folate-based binuclear Mn(II) chelates with 2,2’-bipyridine/1,10-phenanthroline as targeted anticancer agents for colon cancer cells

Type of cells based on folate receptor (FR) expression

Cells

IC50 (µg/ml)

Chelate 1

Chelate 2

FR-Positive cells

HCT116

5.8 ± 0.45

7.2 ± 1.01

HeLa

9.3 ± 1.94

12.4 ± 0.5

Caco-2

9.9 ± 0.37

10 ± 0.31

FR-Negative cells

MCF-7

22.3 ± 1.75

24.3 ± 1.90

A549

24.9 ± 1.33

22.8 ± 1.70

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