Fig. 3 | Scientific Reports

Fig. 3

From: Quantitative 1H-NMR spectroscopy identifies metabolites and lipoprotein subclasses associated with intermediate phenotypes of chronic diseases in the Japanese Nagahama Study

Fig. 3

Phenome-wide significant associations between plasma small molecular weight metabolites and phenotypes in the Nagahama Study population. Plasma concentration of metabolites acquired by 1H NMR metabolomics were tested for evidence of statistically significant association (p < 4.11 × 10–7) with the 944 intermediate phenotypes of chronic diseases in a subset of subjects of the Nagahama Study population (n = 302). Forest plots show the significant associations for each metabolite (A). Manhattan plots illustrate associations of leucine (B) and valine (C) across the 944 phenotypes characterized in the Nagahama Study population. Symbols indicate positive (filled upward triangle) or inverse (filled downward triangle) associations between the metabolites and the phenotypes. Significant associations are labelled with phenotype names and showed by filled triangles. Details of statistics of association between plasma metabolites and phenotypes are shown in Supplementary Table S4. Abd. Cir, Abdominal Circumference; BFM, Body Fat Mass; BMI, Body mass index; CI, Confidence Interval; L-, left; R-, right.

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