Fig. 4

Association analyses between biochemically determined plasma HDL and LDL cholesterol in the Nagahama Study population and metabolites and lipoprotein (sub)classes. ¹H NMR spectroscopy was used to derive quantitative data for small molecular weight metabolites and lipoprotein classes and subclasses which were tested for association with biochemically determined plasma HDL (A) and LDL (B) cholesterol in 302 subjects of the Nagahama Study population. The inner circle displays the -log₁₀(p-value) of each association, and significant associations are shown in orange dots (–Log₁₀(p-value) > 6.40) and lack of association in black dots. The outer circle represents the regression coefficient as beta values for NMR measured compounds associated positively (red dots) or negatively (blue dots) with HDL or LDL cholesterol. The nomenclature used for each lipoprotein (sub)class is given in Supplementary Table S3. Details of statistics of associations between NMR-derived compounds and HDL and LDL cholesterol are given in Supplementary Tables S4 and S5.