Fig. 1
From: Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model

Conditional knockout of Trpv4 in phagocytes does not improve functional recovery after spinal cord injury. (A). Timeline of the experimental procedures with three experimental groups (10 weeks old): (1) Trpv4lox/lox Cx3cr1CreER/+ animals receiving corn oil injections (Ctrl); (2) Trpv4lox/lox without Cx3cr1-CreER receiving tamoxifen injections (Tamoxifen ctrl); (3) Trpv4lox/lox Cx3cr1CreER/+ animals receiving tamoxifen injections (57 mg/kg body weight) (Trpv4 cKO). (B) Functional recovery over 28 days after contusion injury at T8 of the Ctrl (n = 16), Tamoxifen Ctrl (n = 13), and Trpv4 cKO (n = 17) groups of three individual experiments. Two-way ANOVA. Data are presented as means ± SEM. Ctrl, control; cKO, conditional knockout; T8, thoracic level 8; SCI, spinal cord injury; BMS, Basso Mouse Scale.