Fig. 1 | Scientific Reports

Fig. 1

From: Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model

Fig. 1

Conditional knockout of Trpv4 in phagocytes does not improve functional recovery after spinal cord injury. (A). Timeline of the experimental procedures with three experimental groups (10 weeks old): (1) Trpv4lox/lox Cx3cr1CreER/+ animals receiving corn oil injections (Ctrl); (2) Trpv4lox/lox without Cx3cr1-CreER receiving tamoxifen injections (Tamoxifen ctrl); (3) Trpv4lox/lox Cx3cr1CreER/+ animals receiving tamoxifen injections (57 mg/kg body weight) (Trpv4 cKO). (B) Functional recovery over 28 days after contusion injury at T8 of the Ctrl (n = 16), Tamoxifen Ctrl (n = 13), and Trpv4 cKO (n = 17) groups of three individual experiments. Two-way ANOVA. Data are presented as means ± SEM. Ctrl, control; cKO, conditional knockout; T8, thoracic level 8; SCI, spinal cord injury; BMS, Basso Mouse Scale.

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