Fig. 5
From: Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model
Full absence of TRPV4 does not contribute to recovery after spinal cord injury. (A) Functional recovery of 12-week-old Trpv4 WT (n = 6) and Trpv4 KO (n = 6) mice over 28 days after contusion injury at T8, of one individual experiment. (B) Overview of MBP around the lesion of a sagittal spinal cord section at 10, 450, and 900 μm depth. (C) Quantification of lesion volume surrounded by MBP and GFAP+ astrocytes at 28 dpi. Two-way ANOVA (A), Mann–Whitney U test (C). Data are presented as means ± SEM. Scale bar: 1 mm. WT, wild-type; KO, knockout; T8, thoracic level 8; MBP, myelin basic protein; GFAP, glial fibrillary acidic protein; dpi, days post-injury; BMS, Basso Mouse Scale.
