Fig. 1
Single-cell transcriptomic analysis of the normoxic carotid body. (A) UMAP embedding of 9,658 single carotid body cells from rats maintained in standard normoxic conditions (21% O2 tension atmosphere). Transcriptionally similar cell clusters are color-coded and labeled by cell type. (B) Violin plots displaying the expression levels of three of the most highly expressed gene markers for each cell type within the normoxic carotid body. (C) Violin plots displaying transcriptomic generic features for each cluster: top, number of genes being expressed; center, total number of transcripts; bottom, percentage of transcripts corresponding to mitochondrial genes. (D) Violin plots showing the expression of specific sympathoadrenal markers in carotid body cells. Schwann cell and blood cell clusters have been excluded for clarity. (E) UMAP plots depicting the expression of selected sympathoadrenal markers in mesenchymal, neuronal, and progenitor cell clusters within the normoxic carotid body.
