Fig. 6
Merged analysis of O2-sensing capacity between normoxic and hypoxic carotid body cells. (A) UMAP representation of normoxic cell clusters. (B) UMAP representation of hypoxic cell clusters. Note that a few glomus cells and neuroblasts did not complete maturation and their transcriptomic profiles remained as in the normoxic condition. (C) Merged representation of normoxic and hypoxic cell clusters, highlighting glomus cells as the only cell class that significantly changes its transcriptome in response to hypoxia. (D) Violin plot representing the O₂-sensing score for each cell cluster, with a black line indicating the average signature expression in each population. Selective significant differences in O₂-sensing capacity are highlighted by p-values. (E) Violin plots depicting an increased expression in O2-sensing relevant genes under hypoxia, such as Cox4i2, Higd1c and Pc. (F) Dot plot displaying the expression of Olr59 in carotid body cells. Note how the expression of Olr59 decreases along the O2-sensing neuronal lineage, specially under hypoxia. (G) Violin plot depicting the expression of Olr59 in the neuronal lineage.
