Fig. 4
Identification of the common pathways via comparison of pathway enrichments of the trans-regulatory, cis-regulatory targets of differential expression lncRNAs between TP53-R175H cells and TP53-WT cells versus pathway enrichments of differential expression mRNAs between the same two cells. (a, b, c) Scatterplot of enriched KEGG pathways of the differentially expressed mRNA, the trans-regulatory targets of differentially expressed lncRNAs and the cis-regulatory targets of differentially expressed lncRNAs between TP53-R175H cells and TP53-WT cells. The vertical axis represents the enriched KEGG pathways. The horizontal axis represents the rich factor (enrichment score)—the ratio of the number of DEGs enriched in certain KEGG pathway to the total number of annotated genes. The higher degree of DEGs enrichment gives the greater value. The size of the dots indicates the number of DEGs enriched in certain pathway, and the color of the dots indicates the range of the adjusted p value which is significant when below 0.05. The red underlines indicate the common pathways. (d, e, f) Scatterplot of enriched Reactome pathways of the differentially expressed mRNA, the trans-regulatory targets of differentially expressed lncRNAs and the cis-regulatory targets of differentially expressed lncRNAs between TP53-R175H cells and TP53-WT cells. The vertical axis represents the enriched Reactome pathways. The horizontal axis represents the rich factor (enrichment score)—the ratio of the number of DEGs enriched in certain Reactome pathway to the total number of annotated genes. The higher degree of DEGs enrichment gives the greater value. The size of the dots indicates the number of DEGs enriched in certain pathway, and the color of the dots indicates the range of the adjusted p value which is significant when below 0.05. The red underlines indicate the common pathways.
