Fig. 5

Identification of the common pathways in prediction TP53-regulated lncRNAs with differential expression. (a) Scatterplot of enriched KEGG pathways of the differentially expressed mRNA between TP53-R175P cells and TP53-WT cells. The vertical axis represents the enriched KEGG pathways. The horizontal axis represents the rich factor (enrichment score)—the ratio of the number of DEGs enriched in certain KEGG pathway to the total number of annotated genes. The higher degree of DEGs enrichment gives the greater value. The size of the dots indicates the number of DEGs enriched in certain pathway, and the color of the dots indicates the range of the adjusted p value which is significant when below 0.05. (b) Scatterplot of enriched Reactome pathways of the differentially expressed mRNA between TP53-R175P cells and TP53-WT cells. The vertical axis represents the enriched Reactome pathways. The horizontal axis represents the rich factor (enrichment score)—the ratio of the number of DEGs enriched in certain Reactome pathway to the total number of annotated genes. The higher degree of DEGs enrichment gives the greater value. The size of the dots indicates the number of DEGs enriched in certain pathway, and the color of the dots indicates the range of the adjusted p value which is significant when below 0.05. (c) Scatterplot of enriched KEGG pathways of the trans-regulatory targets of differentially expressed prediction TP53-regulated lncRNAs between TP53-null control cells and TP53-WT cells. The red underlines indicate the same pathways detected in previous pathway enrichments. (d) Scatterplot of enriched Reactome pathways of the trans-regulatory targets of differentially expressed prediction TP53-regulated lncRNAs between TP53-null control cells and TP53-WT cells. The red underlines indicate the same pathways detected in previous pathway enrichments. (e) Scatterplot of enriched KEGG pathways of the trans-regulatory targets of differentially expressed prediction TP53-regulated lncRNAs between TP53-R175H cells and TP53-WT cells. The red underlines indicate the same pathways detected in previous pathway enrichments. (f) Scatterplot of enriched Reactome pathways of the trans-regulatory targets of differentially expressed prediction TP53-regulated lncRNAs between TP53-R175H cells and TP53-WT cells. The red underlines indicate the same pathways detected in previous pathway enrichments.