Fig. 1

RvD1 restores Bleo-induced alveolar simplification and septal wall thickness. a Representative lung histology stained with hematoxylin and eosin. Magnification, 100 × ; Scale bar, 100 μm. b Mean linear intercept (MLI), radial alveolar count (RAC), and septal thickness (ST). White bar: Control group, black bar: Bleo group, blue bar: Bleo + RvD1 group (500 ng daily for 10 days), gray bar: RvD1 alone group (500 ng RvD1 alone daily for 10 days). Mean ± SD. N = 5–8/group.* p <0.05, † p < 0.001, NS: not significant. The Bleo group displayed impaired alveolarization, increased MLI and ST, and decreased RAC compared to that of the Control group. Treatment with RvD1 improved the alveolar structure and significantly improved the MLI, RAC, and ST values. RvD1 alone had no apparent effect on histological or morphometric analyses.