Fig. 3

Biomarker changes during HDBR. Soluble α-klotho plasma concentrations (A) for CONT (left) and EX (right) at HDT-2, HDT 9 and HDT 15. For ease of viewing these same data are presented following grouping by sex (B); women (left) and men (right). Individual participant data are superimposed on the median and interquartile ranges, with circles representing women and triangles representing men. Total osteocalcin (C), undercarboxylated osteocalcin (D) and undercarboxylated osteocalcin ratio (E) for CONT (left) and EX (right) at HDT-2, HDT 9 and HDT 13. Individual participant data are superimposed on the median and interquartile ranges.