Fig. 3 | Scientific Reports

Fig. 3

From: Empagliflozin reduces liver fibrosis by restoring catechol-O-methyltransferase activity associated with magnesium levels

Fig. 3

Empagliflozin (EMPA) promoted norepinephrine (NE) metabolism in the livers of diabetic mice. (a) Liver NE and (b) normetanephrine (NMN) concentrations were measured in db/ +, db/db control, and db/db EMPA mice. (c) The ratios of NMN to total concentrations of NE and NMN were calculated. (d) Liver S-adenosylmethionine (SAM) and (e) S-adenosylhomocysteine (SAH) concentrations were measured. (f) The ratios of SAH to SAM were calculated. db/ +, n = 5. db/db control, n = 6. db/db EMPA, n = 6. The data are presented as the mean ± SEM. The data were analysed using one-way ANOVA followed by Tukey’s test. *p < 0.05, **p < 0.01.

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