Fig. 3
(A) UMAP plot of single nuclei isolated from hippocampi of AAV-infected animals. Cells clustered into six groups based on genome wide expression patterns. (B) Cell counts, expressed as a proportion, in hippocampi of 6-week-old animals injected with AAV-STOP and AAV-Tau. (C) UMAP plot of single neuronal nuclei isolated from hippocampi of AAV-infected animals, showing 10 clusters of neurons. (D) Cell counts of neuronal subtypes, expressed as a proportion, among the 10 neuron clusters identified in hippocampi of 6-week-old animals injected with AAV-STOP and AAV-Tau. (E) Top 10 pathways (KEGG48,49,50 most significantly regulated in cluster 0 neurons from AAV-Tau animals compared to AAV-STOP. (F) Top 10 pathways (KEGG48,49,50 most significantly regulated in cluster 1 neurons from AAV-Tau animals compared to AAV-STOP.
