Fig. 4

Na⁺ channels parameters from SH-SY5Y and iPSC-derived cortical neurons in constant perfusion of NaCl, ⁶LiCl, ⁷LiCl, ^natLiCl. (a) \(\:{V}_{\text{h}\text{a}\text{l}\text{f}}\) - the half-maximal activation potential. (b) \(\:{G}_{\text{m}\text{a}\text{x}}\) - the maximal conductance. c) \(\:z\) - the apparent valence of the gating charge. Statistical significance was evaluated by one-way ANOVA with Bonferroni’s post hoc test (solid columns represent SHSY-5Y cells, dashed columns represent iPSC-derived cortical neurons; points represent the individual measurements, colored boxes represent the mean, and bars represent SD). The number of replicates (individual cells successfully patched) is \(\:n\:=\:20\) for iPSC-derived cortical neurons and \(\:n\:=\:10\) for SH-SY5Y cells.