Fig. 11 | Scientific Reports

Fig. 11

From: Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming

Fig. 11

MRPL21 knockdown inhibited oxidative phosphorylation and induces mitochondrial dysfunction in neuroblastoma cells. MRPL21 knockdown reduces mitochondrial oxygen consumption in SH-SY5Y (A) and SK-N-BE2 (B) cells. The oxygen consumption rate (OCR) was measured using the Seahorse XFe96 analyzer. Oligomycin, FCCP, and rotenone/antimycin A (ROT/AA) were sequentially added to assess mitochondrial function. (C) MRPL21 knockdown reduces ATP production in SH-SY5Y and SK-N-BE2 cells. MRPL21 knockdown impairs mitochondrial membrane potential in SH-SY5Y (D) and SK-N-BE2 (E) cells.

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