Fig. 2 | Scientific Reports

Fig. 2

From: Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming

Fig. 2

Annotation of cellular subtypes of single-cell samples. (A) Distribution of samples within the cell clusters. (B) Annotation assigned the 13 cell clusters as 9 cell types. (C) Bubble chart of classic markers of 9 cell types. (D) Histogram of cell proportions corresponding to groups. (E) Employed AUCell to score metabolic reprogramming-related genes’ activity at the single-cell level. Metabolic reprogramming scores of Neuroblastoma cells were significantly elevated in the disease group compared to the control group. (F) A total of 136 differentially expressed genes. Ten genes with upregulated and ten with downregulated expression were displayed.

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