Fig. 1 | Scientific Reports

Fig. 1

From: Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions

Fig. 1

Flavonol structure and screening assay results. (A) Flavonol backbone structure. (B) BCRP activity in the absence or presence of the positive inhibitor (novobiocin, 5 µM) in MDCKII-mock and MDCKII-BCRP cells. (C and D) BCRP activity in the absence or presence of flavonols (2 µM) in MDCKII-BCRP. Cells were incubated for 20 min after the treatment. Blue and red dotted lines represent 75% and 50% of BCRP activity (% of control), respectively. *** denotes p < 0.001. Data are expressed as the mean ± SD (n = 3).

Back to article page