Table 1 IC50 values of flavonols on BCRP activity.
Compound no. | Name | IC50 (µM) |
|---|---|---|
- | Novobiocin | 1.43 |
4 | 3,3’-Dihydroxyflavone | 5.61 |
7 | 3,7-Dihydroxyflavone | 3.14 |
8 | 3,7,3’-Trihydroxyflavone | 2.78 |
17 | 3,6-Dihydroxyflavone | 6.73 |
26 | 3,5,7-Trihydroxyflavone (galangin) | 5.40 |
27 | 3,5,7,3’,4’-Pentahydroxyflavone (quercetin) | 2.63 |
29 | 3,5,7,4’-Tetrahydroxy-3’-methoxyflavone (isorhamnetin) | 3.50 |
31 | 3,5,7,2’,4’-Pentahydroxyflavone (morin) | 24.9 |
32 | 3,5,7,3’,4’-Pentahydroxy-8-methylflavone | 2.91 |
37 | 3,4’-Dimethoxyflavone | 1.62 |
39 | 3,3’,4’-Trimethoxyflavone | 3.79 |
43 | 4’-Hydroxy-3,7,3’-trimethoxyflavone | 2.31 |
44 | 3,6-Dimethoxyflavone | 8.20 |
45 | 3,6,3’-Trimethoxyflavone | 8.98 |
46 | 3,6,3’,4’-Tetramethoxyflavone | 1.69 |
47 | 3,6,2’,3’-Tetramethoxyflavone | 15.5 |
48 | 5,7,3’-Trihydroxy-3,4’-dimethoxyflavone | 3.54 |
50 | 5-Hydroxy-3,7,3’,4’-tetramethoxyflavone (retusin) | 2.23 |
51 | 3,5,7-Trimethoxyflavone | 7.06 |
52 | 6,3’-Dihydroxy-3,5,7,4’-tetramethoxyflavone | 3.62 |
53 | 3,5,6,7,4’-Pentamethoxyflavone | 3.62 |
54 | 3,5,6,7,3’,4’-Hexamethoxyflavone | 2.81 |
