Table 4 Pharmacokinetic parameters of sulfasalazine and flavonols following oral administration of sulfasalazine (2 mg/kg) with or without flavonols (5 mg/kg) in rats (n = 5, mean ± SD).

From: Inhibition of breast cancer resistance protein by flavonols: in vitro, in vivo, and in silico implications of the interactions

Parameter

Sulfasalazine

3,4’-Dimethoxyflavone

3,6,3’,4’-Tetramethoxyflavone

Control

+ 3,4’-Dimethoxyflavone

+ 3,6,3’,4’-Tetramethoxyflavone

Cmax (ng/mL)

80.1 ± 15.2

146.4 ± 58.4

162 ± 19 ***

13.5 ± 8.8

13.3 ± 0.6

Tmax (h)

0.438 ± 0.125

0.5 ± 0

0.5 ± 0

0.5 ± 0

0.375 ± 0.144

t1/2 (h)

2.3 ± 1.76

1.76 ± 0.29

2.34 ± 1.23

0.54 ± 0.15

2.24 ± 0.17

AUClast (ng·h/mL)

183 ± 84

327 ± 36 *

319 ± 25 *

12.4 ± 5.0

22.3 ± 1.6

AUCinf (ng·h/mL)

223 ± 99

356 ± 41 *

396 ± 88 *

13.3 ± 4.3

26.8 ± 2.5

  1. AUCinf, area under the plasma concentration–time curve from time 0 to infinity; AUClast, area under the plasma concentration–time curve from time zero to the last quantifiable point; Cmax, maximum concentration; Tmax, time to reach Cmax; t1/2, half-life. * and *** denote p < 0.05 and p < 0.001, respectively, compared to the control group.
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