Fig. 4 | Scientific Reports

Fig. 4

From: The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response

Fig. 4

Comparative analysis of median methylation levels in biopsies and cfDNA across five genes. Panels A–E show paired methylation levels for each individual (n = 22) for genes ABCB1 (A), CHFR (B), HIST1H4F (C), ITGA4 (D), and SPTBN1 (E). Each line connects an individual’s biopsy and cfDNA methylation values. A one-tailed non-parametric Wilcoxon signed-rank test was used to assess whether cfDNA methylation levels were significantly lower than those in biopsies, based on the biological expectation of tumor-derived cfDNA being diluted in plasma. P-values are indicated above each comparison.

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