Table 3 Cytotoxicity and antiviral activity of mixture Mix 1c against influenza A and SARS-CoV-2.

From: Harnessing prebiotic formamide chemistry: a novel platform for antiviral exploration

Cmpd.

CC50a (MDCK)

IC50b

Influenza A

CC50

A549

IC50

Influenza A

CC50

Caco-2

IC50

SARS-CoV-2

Mix 1c

169.6

2.7 ± 1.6

(SIc = 62.8)

16

2.5 ± 1.1

(SI = 6.4)

13.2

3.6 ± 2.0

(SI = 3.7)

  1. aCC50 half-maximal cytotoxic concentration (µg/mL), bIC50 half-maximal inhibitory concentration (µg/mL), cSelectivity Index (SI) = CC50/IC50.
Back to article page