Table 1 Summary of included Studies.

From: Systematic review and meta analysis of mechanical properties of 3D printed denture bases compared to milled and conventional materials

Study

Country

Related Measured Outcomes

Significance

26

Egypt

Flexural Strength

CAD-CAM milled denture base resins (DBRs) exhibited superior flexural strength compared to conventional compression-molded or 3D-printed DBRs, whereas 3D-printed DBRs and polyamide demonstrated the lowest flexural strengths.

27

Egypt

Surface Roughness, Microhardness

Chemical denture cleansers (CDCs) significantly influenced the surface properties of denture base materials (DBMs), with Corega showing the most adverse effects on roughness and color stability, and H2O2 markedly reducing microhardness. Prolonged use of CDCs warrants caution.

16

Egypt

Vickers Hardness, Surface Roughness, Fracture Toughness

Milled specimens displayed lower surface roughness and higher hardness and fracture toughness than 3D-printed specimens, both before and after thermocycling. Thermocycling reduced hardness and fracture toughness while increasing surface roughness in both groups, though it had no impact on water sorption or solubility.

28

India

Fracture Toughness

Formlabs and Dentca (3D-printed) exhibited significantly lower fracture toughness than Leucitone 199 (conventional), while Leucitone 199 was inferior to Avadent (CAD-CAM) in fracture toughness.

29

UK

Flexural strength, Impact strength, and hardness

Fused deposition modeling (FDM) samples, though cost-effective and reproducible, revealed that current testing standards for conventional denture polymers are unsuitable for additive-manufactured materials, necessitating new protocols for clinical implementation.

30

Saudi Arabia

Flexural Strength and Elastic Modulus

Heat-polymerized, AvaDent, and IvoCad materials are viable for denture bases at 1.5 mm thickness, whereas FormLabs and NextDent require a minimum thickness of 2 mm to achieve clinically acceptable flexural properties.

31

Saudi Arabia

Flexural Strength and Flexural Modulus

Milled groups outperformed printed groups in flexural strength and modulus but were more susceptible to aging and cyclic loading. AvaDent showed the highest flexural strength in controls, Dentsply Block in fatigued groups, and Dentca, Dentsply Block, and Keystone in thermocycled groups. Lucitone 3D exhibited the highest flexural strength when repaired with composite.

32

India

Compressive Strength, Flexural Strength, and Hardness

Milled PMMA and thermopressing demonstrated superior compressive strength, while thermopressing also excelled in flexural strength and hardness. The 3D-printed resin exhibited the lowest color stability.

33

Brazil

Candidal adhesion and their effects on the surface, optical, and mechanical properties like surface microhardness, flexural strength, and modulus of elasticity

Despite the growing use of CAD/CAM-fabricated dentures, limited research exists on how denture cleaners affect microbial adhesion and material properties, highlighting the need for further investigation.

34

Romania

Tensile strength, Vickers Hardness

Heat-cured resins remain clinically acceptable due to their surface quality, mechanical properties, and affordability. CAD/CAM milled resins showed the best mechanical properties and surface finishes, while 3D printing is suitable for provisional solutions.

35

Brazil

Knoop Microhardness, Flexural Strength, and Modulus of Elasticity

CAD/CAM-milled resins matched traditional resins in mechanical properties, whereas 3D-printed resins were inadequate for long-term use, though ongoing research aims to improve their performance.

36

USA

Flexural Strength, Fracture Toughness

3D-printed denture base materials exhibited mechanical, optical, and physical properties comparable to conventional and milled materials.

37

Turkey

Vickers Microhardness and Flexural Strength

Graphene-reinforced PMMA showed the highest flexural strength and microhardness, unaffected by thermal cycling, which otherwise reduced these properties in other resins.

38

Italy

Flexural Strength

Polymerization techniques significantly influenced flexural strength in acrylic and composite resins. Temp Print, combined with pink resin powder, emerged as a promising alternative for removable dentures.

39

USA

Fracture Toughness

Milled samples with embedded 3D-printed titanium frameworks exhibited higher impact resistance, flexural strength, and lower elastic deformation compared to non-framework milled or printed samples.

40

Italy

Ultimate Flexural Strength, Flexural Strain, Flexural Modulus

CAD-milled PMMA displayed optimal flexural properties, lowest pre-polishing roughness, and reduced bacterial adhesion after 90 min, though all materials showed similar roughness and microbial adhesion after 16 h.

41

Egypt

Impact Strength, Flexural Strength, and Surface Roughness

Milled specimens had higher flexural and impact strength and lower roughness than 3D-printed specimens. Polishing reduced roughness in printed specimens but had no significant effect on milled ones.

42

Brazil

Flexure Strength

CAD-CAM milled PMMA showed the lowest *C. albicans* biofilm formation and highest flexural strength, while 3D-printed specimens had the lowest strength and highest roughness.

43

Saudi Arabia

Flexural strength, Impact strength, and Surface hardness

3D-printed resin had inferior flexural strength, impact strength, and hardness compared to heat-polymerized resin but superior surface roughness. Thermal cycling reduced hardness and flexural strength while increasing roughness, with no effect on impact strength.

44

Egypt

Surface Hardness, Fracture Toughness

Milled specimens exhibited higher hardness and fracture toughness than 3D-printed specimens before and after immersion in denture cleansers, which reduced these properties in both groups without affecting water sorption or solubility.

7

Korea

Flexural strength and modulus

3D-printed materials demonstrated suitable mechanical properties for hard dental prostheses.

45

Croatia

Flexural Strength, Surface Hardness

Digital denture manufacturing techniques influence residual monomer content, flexural strength, and microhardness, though these factors alone do not guarantee optimal properties.

46

USA

Flexural Strength, Flexural Strain

All digitally fabricated denture base materials met clinical acceptability standards, even after hard relining, though flexural strength varied by material type.

47

USA

Flexural Strength

3D-printed denture base materials exhibited flexural strength comparable to or lower than milled materials, with thermal cycling further reducing their strength.

2

Saudi Arabia

Flexural strength, Elastic modulus, and Surface Hardness

CAD-CAM milled resins surpassed heat-polymerized and 3D-printed resins in flexural strength, modulus, and hardness, though 3D-printed resins remained clinically acceptable.

2

Saudi Arabia

Surface hardness

Denture base resin properties varied, with CAD/CAM and thermoformed resins maintaining hardness and color stability after brushing, though surface roughness was affected.

48

Switzerland

Flexural Strength and Fracture Toughness

CAD-CAM milled and 3D-printed denture resins showed similar biocompatibility and roughness, but milled resins were mechanically superior. Printing orientation and printer type influenced resin strength and roughness.

8

Egypt

Surface Hardness and Impact Strength

CAD/CAM milled resins had the lowest surface roughness and highest impact strength and hardness compared to 3D-printed and polyamide resins.

49

Saudi Arabia

Surface hardness

Denture base material and disinfectants affected surface properties, with lasers producing smoother surfaces and improving CAD/CAM resin hardness, while chemical disinfectants enhanced PMMA hardness.

4

Jordan

Surface hardness, Flexural properties, and Impact strength

3D-printed resins exhibited variations in surface and mechanical properties compared to conventional PMMA, necessitating further research before standardization.

13

Saudi Arabia

Surface Roughness, Flexure strain, Maximum load, Flexure stress at yield, and Flexure modulus

CAD-CAM resins outperformed 3D-printed resins in surface and mechanical properties, with build plate angles having no significant effect on 3D-printed resin roughness.

50

Portugal

Microhardness and Flexural strength

Printed resins had lower microhardness than conventional resins but comparable flexural strength.

32

India

Vickers hardness and Color stability

Milled PMMA showed superior color stability, while tooth-shade resins (milled and 3D-printed) exhibited higher hardness than pink-shade resins. Tooth-shade 3D-printed resin also outperformed pink-shade in color stability and hardness.

51

Brazil

Flexural strength and Elastic modulus

3D-printed resin demonstrated fatigue strength and surface roughness comparable to subtractive and pressed methods, supporting its potential for dental prostheses.

52

Turkey

Flexural strength

Digitally produced denture bases exhibited higher flexural strength than conventionally manufactured bases.

3

Croatia

Flexural strength and Surface hardness

CAD/CAM materials had the highest surface hardness, while 3D-printed materials showed the lowest flexural strength.

53

Turkey

Shear bond strength

Sandblasting was most effective for shear bond strength (SBS) in conventional resins, while laser treatment worked best for additive-manufactured resins. Subtractive resins showed similar SBS across surface treatments except plasma.

54

Germany

Maximum fracture forces

The testing setup effectively evaluated denture fracture behavior, demonstrating that digital design and manufacturing can enhance mechanical stability, particularly with optimized dentition forms.