Fig. 5 | Scientific Reports

Fig. 5

From: Frem2 knockout mice exhibit Fraser syndrome phenotypes and neonatal lethality due to bilateral renal agenesis

Fig. 5

Serial sectioning of newborn (P0) Frem2 pups reveals renal agenesis in knockout mice. Sections down the columns progress below the diaphragm to the pelvic region from the same pup. Sections across each row correspond to the same region of each pup’s body. Hematoxylin and eosin-stained histology sections from Frem2+/+ (A) and Frem2+/- (B) pups exhibit the presence of both kidneys (KID) and a comparable arrangement of organs. Frem2-/- pups display bilateral (C) and unilateral renal agenesis (D). Locations of missing kidneys are labeled with asterisks. Scale bar: A–D 1 mm. Labels: AD adrenal glands, KID kidney, LV liver, LUN lung, I intestines, SP spleen, UB urinary bladder.

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