Fig. 9

Landscape of TRPM4 mutations and correlation with genomic instability. (A) Lollipop plot showing the distribution and frequency of TRPM4 mutations across cancers; R640H/C is the most frequent site. (B) Proportion of mutation types (missense, truncating, etc.) in TRPM4 across pan-cancer samples. (C) Frequency of TRPM4 mutations in each cancer type; UCEC, SKCM, and UCS exhibit highest rates. (D) Association between TRPM4 mRNA expression and copy-number alterations; dot colors indicate mutation type. (E) Summary of mutation subtypes in TRPM4. (F) Radar plot of Spearman correlation between TRPM4 expression and tumor mutational burden (TMB); (G) Radar plot of Spearman correlation between TRPM4 expression and microsatellite instability (MSI).Red lines: positive correlation; blue lines: negative correlation; correlation coefficients are labeled.