Table 2 Summary of Anti-TB Drug Resistance Mutations in 2,005 Isolates.
From: Genomic decoding of drug-resistant tuberculosis transmission in Thailand over three decades
Anti-TB drugs | Gene name | Changes | Our study N = 2,005 | Our study (%) | Global (%) N = 50,7231 |
---|---|---|---|---|---|
INH | katG | Ser315Thr | 1436 | 71·62 | 26·55 |
inhA | c.−777C > T | 182 | 9·08 | 4·06 | |
inhA | Ser94Ala | 29 | 1·45 | 0·62 | |
katG | Ser315Asn | 25 | 1·25 | 0·53 | |
RIF | rpoB | Ser450Leu | 923 | 46·03 | 18·80 |
rpoB | His445Tyr | 209 | 10·42 | 1·21 | |
rpoB | Asp435Val | 114 | 5·69 | 2·30 | |
rpoB | His445Asp | 107 | 5·34 | 1·04 | |
EMB | embB | Gly406Asp | 320 | 15·96 | 0·78 |
embB | Met306Val | 261 | 13·02 | 7·73 | |
embB | Met306Ile | 236 | 11·77 | 5·94 | |
STR | rpsL | Lys43Arg | 931 | 46·43 | 13·49 |
rpsL | Lys88Arg | 74 | 3·69 | 2·55 | |
rrs | n.514A > C | 34 | 1·70 | 2·53 | |
gid | c.102delG | 30 | 1·50 | 1·25 | |
PZA | pncA | Ile31Thr | 289 | 14·41 | 0·05 |
pncA | Ile90Ser | 31 | 1·55 | 0·05 | |
pncA | c.−11A > G | 24 | 1·20 | 0·90 | |
LFX | gyrA | Asp94Gly | 119 | 5·94 | 4·30 |
gyrA | Ala90Val | 88 | 4·39 | 3·15 | |
gyrA | Asp94Ala | 39 | 1·95 | 1·18 | |
MFX | gyrA | Asp94Gly | 119 | 5·94 | 4·30 |
gyrA | Ala90Val | 88 | 4·39 | 3·15 | |
gyrA | Asp94Ala | 39 | 1·95 | 1·18 | |
AMK | rrs | n.1401A > G | 98 | 4·89 | 4·71 |
eis | c.−14C > T | 8 | 0·40 | 0·48 | |
KAN | rrs | n.1401A > G | 98 | 4·89 | 4·71 |
eis | c.−10G > A | 17 | 0·85 | 0·72 | |
eis | c.−14C > T | 8 | 0·40 | 0·48 | |
ETO | ethA | c.639_640delGT | 534 | 26·63 | 0·18 |
inhA | c.−777C > T | 182 | 9·08 | 4·06 | |
inhA | Ser94Ala | 29 | 1·45 | 0·62 | |
PAS | folC | Ser150Gly | 91 | 4·54 | 0·31 |
thyX | c.−16C > T | 76 | 3·79 | 0·75 | |
folC | Glu40Gly | 29 | 1·45 | 0·17 | |
CAP | rrs | n.1401A > G | 98 | 4·89 | 4·71 |
tlyA | c.52_53dupCG | 3 | 0·15 | < 0·001 |