Table 2 Summary of Anti-TB Drug Resistance Mutations in 2,005 Isolates.

From: Genomic decoding of drug-resistant tuberculosis transmission in Thailand over three decades

Anti-TB drugs

Gene name

Changes

Our study

N = 2,005

Our study

(%)

Global (%)

N = 50,7231

INH

katG

Ser315Thr

1436

71·62

26·55

inhA

c.−777C > T

182

9·08

4·06

inhA

Ser94Ala

29

1·45

0·62

katG

Ser315Asn

25

1·25

0·53

RIF

rpoB

Ser450Leu

923

46·03

18·80

rpoB

His445Tyr

209

10·42

1·21

rpoB

Asp435Val

114

5·69

2·30

rpoB

His445Asp

107

5·34

1·04

EMB

embB

Gly406Asp

320

15·96

0·78

embB

Met306Val

261

13·02

7·73

embB

Met306Ile

236

11·77

5·94

STR

rpsL

Lys43Arg

931

46·43

13·49

rpsL

Lys88Arg

74

3·69

2·55

rrs

n.514A > C

34

1·70

2·53

gid

c.102delG

30

1·50

1·25

PZA

pncA

Ile31Thr

289

14·41

0·05

pncA

Ile90Ser

31

1·55

0·05

pncA

c.−11A > G

24

1·20

0·90

LFX

gyrA

Asp94Gly

119

5·94

4·30

gyrA

Ala90Val

88

4·39

3·15

gyrA

Asp94Ala

39

1·95

1·18

MFX

gyrA

Asp94Gly

119

5·94

4·30

gyrA

Ala90Val

88

4·39

3·15

gyrA

Asp94Ala

39

1·95

1·18

AMK

rrs

n.1401A > G

98

4·89

4·71

eis

c.−14C > T

8

0·40

0·48

KAN

rrs

n.1401A > G

98

4·89

4·71

eis

c.−10G > A

17

0·85

0·72

eis

c.−14C > T

8

0·40

0·48

ETO

ethA

c.639_640delGT

534

26·63

0·18

inhA

c.−777C > T

182

9·08

4·06

inhA

Ser94Ala

29

1·45

0·62

PAS

folC

Ser150Gly

91

4·54

0·31

thyX

c.−16C > T

76

3·79

0·75

folC

Glu40Gly

29

1·45

0·17

CAP

rrs

n.1401A > G

98

4·89

4·71

tlyA

c.52_53dupCG

3

0·15

 < 0·001

  1. There could be > 1 mutation associated with resistance to a single drug. 1The global percentage of anti-TB drug resistance mutations identified by TB-Profiler database; INH, Isoniazid; RIF, Rifampicin; EMB, Ethambutol; STR, Streptomycin; PZA, Pyrazinamide; LFX, Levofloxacin; MFX, Moxifloxacin; AMK, Amikacin, KAN, Kanamycin; ETO, Ethionamide; PAS, Para-aminosalicylic acid; CAP, Capreomycin.