Fig. 7

Quasi - temporal analysis of key cell subtypes and their prognostic gene expression patterns. (a) UMAP plot of epithelial cell subtypes. Different colors represent different subtypes of epithelial cells; (b) Distribution of key epithelial cells on the differentiation trajectory. The lines signify the differentiation trajectory, and dots of different colors represent different subtypes of epithelial cells, indicating the position and distribution of each subtype during the differentiation process; (c) Plot of prognostic genes (such as BPI, RASGRP1, SEMA4A, etc.) in key epithelial cells along the pseudo - time. The abscissa is the pseudo - time, and the ordinate is the relative gene expression level. Curves of different colors represent different prognostic genes; (d) UMAP plot of fibroblast subtypes. Different colors distinguish different subtypes of fibroblasts, presenting the distribution characteristics of fibroblast subtypes; (e) Distribution of key fibroblasts on the differentiation trajectory. (f) Plot of prognostic genes (such as MASP1, RASGRP1, SEMA4A, etc.) in key fibroblasts along the pseudo - time. With the pseudo - time as the abscissa and the relative gene expression level as the ordinate, curves of different colors correspond to different prognostic genes. The abscissa is the pseudo - time, the ordinate is the relative gene expression level, and curves of different colors represent the corresponding prognostic genes.