Table 1 Baseline clinical characteristics of patients.
Characteristics | Training set (n = 189) | Internal testing set (n = 82) | External testing set (n = 78) | p |
|---|---|---|---|---|
Age (years), mean ± SD | 61.2 ± 8.3 | 62.6 ± 8.1 | 62.1 ± 7.2 | 0.355 |
Sex | 0.842 | |||
Female | 10 (5.3%) | 3 (3.7%) | 4 (5.1%) | |
Male | 179 (94.7%) | 79 (96.3%) | 74 (94.9%) | |
Smoking status | 0.164 | |||
Yes | 169 (89.4%) | 79 (96.3%) | 70 (89.7%) | |
No | 20 (10.6%) | 3 (3.7%) | 8 (10.3%) | |
Alcohol | 0.290 | |||
Yes | 136 (72.0%) | 54 (65.9%) | 49 (62.8%) | |
No | 53 (28.0%) | 28 (34.1%) | 29 (37.2%) | |
Location | 0.156 | |||
Supraglottic | 50 (26.5%) | 14 (17.1%) | 19 (24.4%) | |
Glottic | 133 (70.4%) | 62 (75.6%) | 58 (74.4%) | |
Subglottic | 6 (3.2%) | 6 (7.3%) | 1 (1.3%) | |
Differentiation | 0.052 | |||
Poor | 41 (21.7%) | 8 (9.8%) | 11 (14.1%) | |
Moderate | 62 (32.8%) | 31 (37.8%) | 36 (46.2%) | |
Well | 86 (45.5%) | 43 (52.4%) | 31 (39.7%) | |
Clinical T stage | 0.673 | |||
T1 | 40 (21.2%) | 13 (15.9%) | 13 (16.7%) | |
T2 | 49 (25.9%) | 24 (29.3%) | 27 (34.6%) | |
T3 | 75 (39.7%) | 30 (36.6%) | 27 (34.6%) | |
T4 | 25 (13.2%) | 15 (18.3%) | 11 (14.1%) | |
Clinical N stage | 0.322 | |||
N0 | 137 (72.5%) | 59 (72.0%) | 63 (80.8%) | |
≥N1 | 52 (27.5%) | 23 (28.0%) | 15 (19.2%) | |
Clinical TNM stage | 0.478 | |||
I | 36 (19.0%) | 11 (13.4%) | 13 (16.7%) | |
II | 36 (19.0%) | 20 (24.4%) | 23 (29.5%) | |
III | 80 (42.3%) | 31 (37.8%) | 27 (34.6%) | |
IV | 37 (19.6%) | 20 (24.4%) | 15 (19.2%) | |
Laryngectomy | 0.519 | |||
Partial | 128 (67.7%) | 51 (62.2%) | 48 (61.5%) | |
Total | 61 (32.3%) | 31 (37.8%) | 30 (38.5%) | |
Adjuvant therapy | 0.147 | |||
No | 114 (60.3%) | 48 (58.5%) | 37 (47.4%) | |
Yes | 75 (39.7%) | 34 (41.5%) | 41 (52.6%) | |
RFS (months), median (IQR) | 54.0 (23.0, 66.0) | 47.5 (25.0, 62.8) | 40.5 (28.5, 51.8) | 0.061 |
