Table 2 Overview of the response across the different dTHP-1 phenotypes to the different morphologies of the carbon-based nms, highlighting their different sensitivities.

From: Towards a harmonized testing strategy for nanofibers by integrating toxicological screening and proteomic profiling

 

Assay

M0

M1

M2

Baseline Toxicity

LDH

Acceptable (23%)

Too high (55%)

Too high (40%)

Dose - Response

LDH

Yes

–

–

WST-1

Yes

Yes

–

TNF-α

Possible*

–

–

  1. The comparison is based on two cytotoxicity assays, LDH and WST-1, along with a TNF-α release assay as an inflammatory readout. *A positive trend was observed, however, a significant response relative to the control was only observed at the highest concentration tested.
Back to article page