Table 3 KEGG pathway enrichment analysis of significantly altered proteins as identified by proteomic measurements for Printex-90 and Mitsui-7.

From: Towards a harmonized testing strategy for nanofibers by integrating toxicological screening and proteomic profiling

KEGG Pathway

25 µg/mL

50 µg/mL

Printex-90

Cholesterol metabolism

4 of 48 (0.0016)

6 of 48 (0.00026)

Ribosome

-

10 of 131 (1.20e-05)

Spliceosome

-

7 of 132 (0.0034)

DNA replication

-

4 of 36 (0.0096)

Mitsui-7

Lysosome

14 of 125 (1.03e-06)

25 of 125 (2.47e-08)

Shigellosis

13 of 218 (0.0015)

-

Metabolic pathways

-

133 of 1435 (7.20e-17)

Carbon metabolism

-

34 of 116 (2.65e-15)

Protein processing in ER

-

30 of 163 (4.39e-09)

Parkinson disease

-

36 of 236 (4.40e-09)

  1. Numbers indicate how many proteins were detected as significantly altered out of the total of proteins belonging to that particular KEGG pathway. Numbers in brackets represent the FDR calculated for the enrichment of that pathway. Only the top 5 KEGG pathways are displayed if the FDR < 0.01.
Back to article page