Fig. 5 | Scientific Reports

Fig. 5

From: Profiling disease experience in patients living with brain aneurysms by analyzing multimodal clinical data and quality of life measures

Fig. 5

Profiling Patients living with Brain Aneurysms. “Residual Brain Damage Post-Rupture” characterizes patients with significant residual brain parenchymal damage following an acute aneurysm rupture, associated with prolonged work incapacity and reduced physical and mental Quality of Life (QoL). This group includes patients who underwent interventional occlusion of their acutely ruptured aneurysms. The first associated Sub-Profile “Trauma-induced Impairment and Quality of Life” includes individuals whose traumatic experiences cause emotional and psychomotor impairment, affecting their daily tasks. The second associated Sub-Profile “Brain Lesions and Functional Disability” focuses on patients with increased brain lesion burden correlating with the severity of vasospasm. These patients experience reduced physical functionality, particularly in performing moderate to heavy tasks and self-care abilities, impacting their overall QoL. “Sex Disparity in Aneurysm Impact” highlights a sex disparity where women report lower physical and mental QoL despite similar vasospasm severity compared to men, suggesting that women tend to exhibit heightened emotional responses to stress, influencing their self-assessed QoL. “Persistent Anxiety and Quality of Life” encompasses individuals with monitored residual perfused aneurysms experiencing diminished physical and mental QoL. Anxiety over living with an untreated aneurysm leads to self-imposed activity reduction, impacting their QoL but not strongly associated with prolonged work disability. “Stable Aneurysms in Older Adults” encompasses older individuals with long-term stable aneurysms who do not require treatment, experiencing reduced work disability due to watchful waiting strategies. “Chronic Pain and Functional Limitations” addresses the impact of chronic pain on QoL, correlating with decreased capacity for daily tasks and heightened fatigue. These patients exhibit psychomotor inhibition, affecting their functionality in familial and social contexts.

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