Fig. 4
From: Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery
Cytokine concentrations in pre-bypass ultrafiltration effluent. a-b) Figure illustrates the spot concentrations of cytokines in the pre-bypass ultrafiltration (PBUF) effluent during the terminal phase of PBUF in relation to the concomitant mediator concentrations of CPB priming in a) low concentration range and b) high concentration range. The selection of these eight cytokines presented was based on their levels in the prime after PBUF, which exceeded the patient’s baseline. c-f) The figure depicts the density plots of the overall distribution of cytokine concentrations in CPB priming (red) and PBUF effluent (blue) for four exemplary cytokines. The height of the curve at a given point along the x-axis indicates the relative likelihood of the concentration of IL-15, IL-5, MIF and VCAM-1 in the respective sample type. Strong overlap indicates convergence of cytokine concentrations in the PBUF effluent and therefore more efficient cytokine removal.
