Table 2 Filtration of selected cytokines.

From: Pre-bypass ultrafiltration reduces cytokine burden of blood prime in pediatric cardiac surgery

Cytokine

Priming solution after PBUF

PBUF effluent

PBUF removal effect

 

Median

(IQR)

(Out of 22)

Median

(IQR)

(Out of 19)

(SD)

 

[pg/ml]

[pg/ml]

 

MIF

1902.82

(1517.94)

(22)

923.20

(811.77)

(19)

50.41%

(42.50%)

IL-15

337.26

(106.91)

(18)

305.89

(136.21)

(13)

85.73%

(52.65%)

CCL11/Eotaxin

92.49

(66.75)

(22)

13.82

(15.06)

(19)

18.69%

(15.06%)

CCL2/MCP-1

22.38

(15.95)

(22)

8.50

(9.08)

(19)

54.66%

(31.58%)

VEGF

110.43

(56.66)

(18)

122.28

(57.94)

(14)

97.73%

(83.92%)

IL-5

27.35

(16.62)

(21)

18.59

(16.50)

(5)

8.97%

(22.11%)

VCAM-1

2.89

(1.70)

(6)

53.41

(48.79)

(18)

0.67%

(1.03%)

ICAM-1

13,614.31

(8532.63)

(22)

486.5

(576.71)

(19)

2.19%

(3.22%)

  1. Comparison of the concentration (pg/mL) of 8 out of 50 cytokines that were detected at or above the median preoperative baseline values in our patient cohort. Concentrations are shown for the priming solution after pre-bypass ultrafiltration (PBUF) and in the PBUF effluent. Different removal effects were observed for individual cytokines. A comprehensive list of all mediator concentrations and their removal effect by PBUF is provided in Supplementary Table S3.
  2. CCL, Chemokine C–C motif ligand; ICAM, Intracellular adhesion molecule; IL, Interleukin; IQR, Interquartile range; MCP, Monocyte chemotactic protein; MIF; Macrophage migration inhibitory factor; PBUF, Pre-bypass ultrafiltration; SD, standard deviation; VCAM, Vascular cell adhesion molecule, VEGF, Vascular endothelial growth factor.