Table 4 Assessment of the impact of a topical formulation on reference microorganisms occurring in the natural microbiome of human skin.
Strain no | Sample no | Cell viability [CFU g-1] | Cell viability [log CFU g-1] | Cell viability after 2 h [CFU g-1] | Cell viability [log CFU g-1] | Reduction [log CFU g-1] | Cell viability after 24 h [CFU g-1] | Cell viability [log CFU g-1] | Reduction [log CFU g-1] | P value for 24 h log reduction |
|---|---|---|---|---|---|---|---|---|---|---|
S. epidermidis | E1 | 1.4 × 107 | 7.15 | 2.4 × 107 | 7.38 | + 0.23 (± 0.1) | 3.75 × 107 | 7.57 | + 0.42 (± 0.02) | 0.0025 |
E2 | 1.15 × 107 | 7.06 | 1.67 × 107 | 7.22 | + 0.16 (± 0.03) | 2.23 × 107 | 7.34 | + 0.28 (± 0.03) | ||
S. aureus | E1 | 3.49 × 107 | 7.54 | 1.3 × 107 | 7.11 | -0.43 (± 0.08) | 7.58 × 106 | 6.87 | -0.67 (± 0.01) | < 0.0001 |
E2 | 2.4 × 107 | 7.38 | 1.0 × 106 | 6 | -1.38 (± 0.05) | 5.96 × 105 | 5.78 | -1.60 (± 0.02) | ||
M. luteus | E1 | 4.68 × 106 | 6.67 | 1.05 × 107 | 7.02 | + 0.35 (± 0.01) | 2.54 × 107 | 7.4 | + 0.73 (± 0.02) | 0.0025 |
E2 | 3.9 × 107 | 7.59 | 1.24 × 108 | 8.09 | + 0.50 (± 0.02) | 1.5 × 108 | 8.17 | + 0.59 (± 0.03) | ||
C. neoformans | E1 | 1.3 × 106 | 6.11 | 3.99 × 105 | 5.60 | -0.5 (± 0.05) | 7.27 × 104 | 4.86 | -1.25 (± 0.01) | < 0.0001 |
E2 | 2.19 × 106 | 6.34 | 3.9 × 105 | 5.59 | -0.75 (± 0.1) | 3.3 × 103 | 3.52 | -2.82 (± 0.02) | ||
C. albicans | E1 | 2.32 × 106 | 6.36 | 2.0 × 106 | 6.30 | -0.06 (± 0.02) | 1.58 × 106 | 6.20 | -0.16 (± 0.02) | 0.001 |
E2 | 1.77 × 106 | 6.25 | 1.13 × 106 | 6.05 | -0.20 (± 0.03) | 0.9 × 106 | 5.95 | -0.30 (± 0.02) | ||
E. coli | E1 | 2.09 × 105 | 5.32 | 1.2 × 105 | 5.08 | -0.24 (± 0.03) | 9.36 × 104 | 4.97 | -0.35 (± 0.03) | < 0.0001 |
E2 | 2.5 × 105 | 5.40 | 1.1 × 105 | 5.04 | -0.36 (± 0.02) | 2.68 × 104 | 4.43 | -0.97 (± 0.02) | ||
S. capitis subsp. urealyticus | E1 | 2.38 × 108 | 8.38 | 4.29 × 108 | 8.63 | + 0.25 (± 0.01) | 4.5 × 108 | 8.65 | + 0.27 (± 0.1) | 0.6372 |
E2 | 2.53 × 108 | 8.40 | 4.14 × 108 | 8.62 | + 0.22 (± 0.02) | 4.41 × 108 | 8.64 | + 0.24 (± 0.02) | ||
S. hominis | E1 | 1.38 × 107 | 7.13 | 1.55 × 107 | 7.19 | + 0.06 (± 0.01) | 2.96 × 107 | 7.47 | + 0.34 (± 0.02) | 0.0324 |
E2 | 1.54 × 107 | 7.19 | 2.5 × 107 | 7.39 | + 0.20 (± 0.05) | 2.68 × 107 | 7.43 | + 0.24 (± 0.05) |
