Table 2 Overview of the dissolution test conditions.

From: Medicine quality assessment in Nepal using semi randomised sampling and evaluation of a small scale dissolution test and portable Raman spectrometers

API

Apparatus type

Medium

Rotation speed

Temperature

Testing time

AZM

Apparatus 2: Paddle

pH 6.0 buffer

75 rpm

37.0 °C ± 0.5 °C

30 min

CFIX

Apparatus 2: Paddle

pH 7.2 buffer

100 rpm

37.0 °C ± 0.5 °C

45 min

ESM

Apparatus 2: Paddle

Acid stage:

0.1 M HCl

Buffer stage:

pH 6.8 buffer

100 rpm

37.0 °C ± 0.5 °C

Acid stage:

120 min

Buffer stage:

30 min

LST

Apparatus 2: Paddle

Distilled, deaerated water

50 rpm

37.0 °C ± 0.5 °C

30 min

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