Table 3 Correlation between re-emergence of non-malignant B cells and recovery of blood counts and polyclonal antibody production after treatment. Table depicting spearman’s correlation coefficients between non-malignant clusters with a Naïve or memory phenotype, measured at early or late post-treatment timepoints, and components of the full blood count and serum Immunoglobulin levels. Statistically significant correlations are shown in bold. *P < 0.05, **P < 0.01, ***P < 0.001. \(^{\dagger}\)At the early post-treatment timepoint, one patient was excluded due to missing serum Immunoglobulin data, while an additional patient had available data for IgM and IgA but lacked information on IgG levels. One patient was excluded at the late post-treatment timepoint for the same reason.

From: Re-emergence of circulating non-malignant B cells as a prognostic biomarker in chronic lymphocytic leukaemia

Post-treatment timepoint

Early (n = 59)

Late (n = 39)

Non-malignant B clusters

CD27-CD38+

(naïve)

CD27+CD38-(memory)

CD27-CD38+

(naïve)

CD27+CD38-(memory)

Full blood count

Hb

0.36**

0.29*

0.17

0.26

Neutrophil count

0.37**

0.17

0.26

0.06

Platelet count

0.32*

0.12

0.41*

0.40*

Serum immunoglobulin concentration\(^{\dagger}\)

IgA

0.14

0.40**

0.08

0.33*

IgM

−0.06

0.14

0.33*

0.43**

IgG

0.02

0.37**

0.15

0.33*