Fig. 4

Effect of treatment on MSU-induced pathological changes in knee joints in different experimental groups: (a) Photomicrograph, articular surface showing normal histological structure (arrows) of negative control group (H&E, scale bar 100 µm). (b) Photomicrograph, synovial membrane showing normal histological structure (arrow) of negative control group (H&E, scale bar 100 µm). (c) Photomicrograph, MSU-induced knee showing edema of synovial membrane (arrow) (H&E, scale bar 100 µm). (d) Photomicrograph, MSU-induced knee showing destruction of bone (arrow) (H&E, scale bar 100 µm). (e) Photomicrograph, MSU-induced knee showing irregular articular surface and necrosis of chondrocytes (arrow) (H&E, scale bar 100 µm). (f) Photomicrograph, MSU-induced knee treated with BERB (50 mg/kg/day) showing smooth articular surface (arrows) (H&E, scale bar 100 µm). (g) Photomicrograph, MSU-induced knee treated with BERB (50 mg/kg/day) showing moderate synovial membrane edema (arrow) (H&E, scale bar 100 µm). (h) Photomicrograph, MSU-induced knee treated with Para (50 mg/kg/day) showing mildly destructed articular surface (arrow) (H&E, scale bar 100 µm).